avatrombopag mechanism

2004 Feb;113(3):474-81. doi: 10.1172/JCI18712. [, Lutz JD, Isoherranen N: Prediction of relative in vivo metabolite exposure from in vitro data using two model drugs: dextromethorphan and omeprazole. Salicylic acid was measured at 24 hours following a single dose of extended-release acetylsalicylic acid 21. 2016 Apr;68(2):357-418. doi: 10.1124/pr.115.011833. Epub 2004 Sep 8. [. Pharm Res. [, Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Tazobactam broadens the spectrum of piperacillin 11 and ceftolozane 14 by making them effective against organisms that express beta-lactamase and would normally degrade them. 2002 Apr;19(4):457-62. doi: 10.1023/a:1015191511817. 1997 Sep;52(3):421-9. [, Nam S, Williams A, Vultur A, List A, Bhalla K, Smith D, Lee FY, Jove R: Dasatinib (BMS-354825) inhibits Stat5 signaling associated with apoptosis in chronic myelogenous leukemia cells. [, Levy G: Clinical pharmacokinetics of aspirin. In the setting of acute myocardial infarction, or before percutaneous interventions, the extended-release form of acetylsalicylic acid should not be used. [, Faassen F, Vogel G, Spanings H, Vromans H: Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs. [, Ohno S, Kawana K, Nakajin S: Contribution of UDP-glucuronosyltransferase 1A1 and 1A8 to morphine-6-glucuronidation and its kinetic properties. 2012;7(10):e48208. Br J Pharmacol. 2004 Nov;48(11):4301-5. carbamazepine will decrease the level or effect of avatrombopag by affecting hepatic/intestinal enzyme CYP3A4 metabolism. The risk or severity of hypotension and CNS depression can be increased when Acetophenazine is combined with Morphine. Epub 2011 Oct 18. Morphine reaches steady-state concentrations after 24-48 hours.1 Parenteral morphine has a Tmax of 15 minutes and oral morphine has a Tmax of 90 minutes, with a Cmax of 283nmol/L.7,8 The AUC of morphine is 225-290nmol*h/L.8, The volume of distribution of morphine is 5.31L/kg.6 Morphine-6-glucuronide has a volume of distribution of 3.61L/kg.6, Morphine is 35% protein bound, the metabolite morphine-3-glucuronide is 10% protein bound, and morphine-6-glucuronide is 15% protein bound.4, Morphine is 90% metabolized by glucuronidation by UGT2B7 and sulfation at positions 3 and 6.4 Morphine can also be metabolized to codeine, normorphine, and morphine ethereal sulfate.6, Hover over products below to view reaction partners, 70-80% of an administered dose is excreted within 48 hours.6 Morphine is predominantly eliminated in the urine with 2-10% of a dose recovered as the unchanged parent drug.4 7-10% of a dose of morphine is eliminated in the feces.13, The apparent clearance of intravenous or subcutaneous morphine is 1600 mL/min.8, The LD50 is 0.78g/mL in males and 0.98g/mL in females.9, Patients experiencing an overdose present with respiratory depression, somnolence, skeletal muscle flaccidity, cold and clammy skin, miosis, and mydriasis. 1992. This reaction requires the hydroquinone (reduced) form of K3, menadiol, produced by an unidentified enzyme. Axitinib: Epub 2006 Jan 24. 2014 Aug;24(8):409-25. doi: 10.1097/FPC.0000000000000062. Systemic or oral antifungals may decrease activity of probiotic. Epub 2016 Aug 9. Epub 2010 Apr 27. 1981 Apr 9;70(4):501-9. [, El-Sankary W, Bombail V, Gibson GG, Plant N: Glucocorticoid-mediated induction of CYP3A4 is decreased by disruption of a protein: DNA interaction distinct from the pregnane X receptor response element. Use immediate-release formulations in scenarios requiring rapid onset of action Label,21. Use our structured and evidence-based datasets to unlock new insights and accelerate drug research. (acetylsalicylic Acid) Tab 325mg USP. 10 Hydrocortisone has a wide therapeutic index 8 and a moderate duration of action. dronedarone. Important note regarding use of the extended-release formulation 21. Excitation of cardiac muscle involves the activation of a slow calcium inward current that is induced by L-type slow calcium channels, which are voltage-sensitive, Avatrombopag: The metabolism of Diltiazem can be increased when combined with Avatrombopag. eCollection 2018. Avoid or Use Alternate Drug. Clin Pharmacokinet. 2002 Jan 1;30(1):412-5. 2011 Oct;3(4):273-6. doi: 10.4168/aair.2011.3.4.273. J Pharmacol Exp Ther. The metabolism of Acetaminophen can be increased when combined with Hydrocortisone. Int J Cancer. dronedarone. Mechanism of action. Improve clinical decision support with information on. Tumour Biol. 2009 Oct;158(4):1153-64. doi: 10.1111/j.1476-5381.2009.00383.x. [, Kneidinger M, Schmidt U, Rix U, Gleixner KV, Vales A, Baumgartner C, Lupinek C, Weghofer M, Bennett KL, Herrmann H, Schebesta A, Thomas WR, Vrtala S, Valenta R, Lee FY, Ellmeier W, Superti-Furga G, Valent P: The effects of dasatinib on IgE receptor-dependent activation and histamine release in human basophils. Menopause. Blood. J Pharmacol Exp Ther. 8,9,10 Nitrofurantoin is converted by bacterial nitroreductases to electrophilic intermediates which inhibit the citric acid cycle as well as synthesis of DNA, RNA, and protein. eCollection 2018. Grapefruit may reduce the CYP3A4 metabolism of dasatinib, increasing its serum levels. 2010;184:83-102. doi: 10.1007/978-3-642-01222-8_7. [, Bossuyt X, Muller M, Hagenbuch B, Meier PJ: Polyspecific drug and steroid clearance by an organic anion transporter of mammalian liver. Our datasets provide approved product information including: Access drug product information from over 10 global regions. 2004;28(2):107-13. doi: 10.1016/j.cdp.2004.01.001. 1998 Aug;18(4):332-7. 2002;507:571-7. J Clin Pharmacol. Losartan is an angiotensin II receptor blocker used to treat hypertension, diabetic nephropathy, and to reduce the risk of stroke. Generic Name Nitrofurantoin DrugBank Accession Number DB00698 Background. Epub 2007 Apr 11. Acetylsalicylic acid has the ability to bind to and acetylate many proteins, hormones, DNA, platelets, and hemoglobin Label. The metabolism of Dasatinib can be increased when combined with Abatacept. 2012 Jan;114(1):122-8. doi: 10.1213/ANE.0b013e318232e922. This information should not be interpreted without the help of a healthcare provider. The main targets of Dasatinib, are BCRABL, SRC, Ephrins and GFR. Pol J Pharmacol. Innovative Manufacturing and Distribution Services Inc. Murfreesboro Pharmaceutical Nursing Supply. The serum concentration of Dasatinib can be increased when it is combined with Abrocitinib. Epub 2006 Mar 23. Epub 2006 Aug 8. 11. Pharmacogenet Genomics. 10 Hydrocortisone has a wide therapeutic index 8 and a moderate duration of action. 2006 May;69(5):1527-33. Mol Pharmacol. 2 Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as Pharmacodynamics. The rate of salicylate is often variable, ranging from 10% to 85% in the urine, and heavily depends on urinary pH. [, Schwartz KA: Aspirin resistance: a review of diagnostic methodology, mechanisms, and clinical utility. 2006 Oct 31;6:1398-404. selumetinib. Psychoneuroendocrinology. Acetylsalicylic acid (ASA) blocks prostaglandin synthesis. [, Serres M, Viac J, Comera C, Schmitt D: Expression of annexin I in freshly isolated human epidermal cells and in cultured keratinocytes. It is non-selective for COX-1 and COX-2 enzymes 9,10,11. 2008 Apr;36(4):688-94. doi: 10.1124/dmd.107.019281. J Clin Endocrinol Metab. The absorption is unaffected by food. [, Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Easily compare up to 40 drugs with our drug interaction checker. 2016 Apr 15;2016(1):146-7. doi: 10.1093/emph/eow009. 1,6 Patients should stop taking the medication if [, Schwab D, Fischer H, Tabatabaei A, Poli S, Huwyler J: Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. [, Grasmader K, Verwohlt PL, Rietschel M, Dragicevic A, Muller M, Hiemke C, Freymann N, Zobel A, Maier W, Rao ML: Impact of polymorphisms of cytochrome-P450 isoenzymes 2C9, 2C19 and 2D6 on plasma concentrations and clinical effects of antidepressants in a naturalistic clinical setting. Absorption. Pharmacodynamics. Generic Name Morphine DrugBank Accession Number DB00295 Background. [, McDonagh EM, Boukouvala S, Aklillu E, Hein DW, Altman RB, Klein TE: PharmGKB summary: very important pharmacogene information for N-acetyltransferase 2. Drug Metab Dispos. Generic Name Morphine DrugBank Accession Number DB00295 Background. For reducing the risk of transient ischemic attacks (TIA) and to prevent atherothrombotic cerebral infarction (in conjunction with other treatments) Label. The presence of this polymorphism in CYP2C19 is associated with poor metabolism of doxepin. (Review). 2008 Jan;107(2):303. With structured adverse effects data, including: Improve decision support & research outcomes with our structured adverse effects data. Avoid life-threatening adverse drug events & improve clinical decision support. Eur J Pharmacol. [, Authors unspecified: Randomised trial of intravenous streptokinase, oral aspirin, both, or neither among 17,187 cases of suspected acute myocardial infarction: ISIS-2. [, Stevenson MA, Zhao MJ, Asea A, Coleman CN, Calderwood SK: Salicylic acid and aspirin inhibit the activity of RSK2 kinase and repress RSK2-dependent transcription of cyclic AMP response element binding protein- and NF-kappa B-responsive genes. Use our structured and evidence-based datasets to unlock new insights and accelerate drug research. 2002 Dec;303(3):1029-37. Acetylsalicylic acid is hydrolyzed in the plasma to salicylic acid. Am J Physiol Regul Integr Comp Physiol. 1980 Nov;47(5):371-6. 2016 Aug;164:170-82. doi: 10.1016/j.pharmthera.2016.04.010. Epub 2012 Dec 26. [, Zhang T, Zhu Y, Gunaratna C: Rapid and quantitative determination of metabolites from multiple cytochrome P450 probe substrates by gradient liquid chromatography-electrospray ionization-ion trap mass spectrometry. 1999 Mar;16(3):408-14. This information should not be interpreted without the help of a healthcare provider. 1,6 Patients should stop taking the medication if 2004 Sep;89(9):4628-33. doi: 10.1210/jc.2004-0379. [, Stuart-Harris R, Joel SP, McDonald P, Currow D, Slevin ML: The pharmacokinetics of morphine and morphine glucuronide metabolites after subcutaneous bolus injection and subcutaneous infusion of morphine. 2001 Nov;15(13):2463-70. Acetylsalicylic acid may decrease the excretion rate of Abacavir which could result in a higher serum level. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial infarction (MI) Label. [, Sneader W: The discovery of aspirin: a reappraisal. Easily compare up to 40 drugs with our drug interaction checker. Discover Part 6 of the Quality Data series: tertiary amino compound, N-arylpiperazine, N-(2-hydroxyethyl)piperazine, aminopyrimidine, monocarboxylic acid amide, organochlorine compound, 1,3-thiazole, secondary amino compound (, Accelerated phase chronic myologenic leukemia, Proto-oncogene tyrosine-protein kinase Src, Mast/stem cell growth factor receptor Kit, Platelet-derived growth factor receptor beta, Signal transducer and activator of transcription 5B, Nuclear receptor subfamily 4 group A member 3, Mitogen-activated protein kinase kinase kinase MLT, L01EA BCR-ABL tyrosine kinase inhibitors, L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS, Antineoplastic and Immunomodulating Agents, Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Inhibitors (weak), Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A5 Substrates with a Narrow Therapeutic Index, Drugs causing inadvertant photosensitivity, P-glycoprotein substrates with a Narrow Therapeutic Index, Chronic Phase Phase Chronic Myelogenous Leukemia (CML), Chronic Myeloid Leukemia in Chronic Phase, Leukemia Chronic Myelogenous Leukemia (CML), Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Predicted MS/MS Spectrum - 10V, Positive (Annotated), Predicted MS/MS Spectrum - 20V, Positive (Annotated), Predicted MS/MS Spectrum - 40V, Positive (Annotated), Predicted MS/MS Spectrum - 10V, Negative (Annotated), Predicted MS/MS Spectrum - 20V, Negative (Annotated), Predicted MS/MS Spectrum - 40V, Negative (Annotated), splash10-000m-0390000000-8a413cb9e53d14cbe10a, splash10-000i-0011900000-4dac51b915117532ebe0, Dimethylaniline monooxygenase [N-oxide-forming] 3, ATP-binding cassette sub-family G member 2. [, Bergan T, Ortengren B, Westerlund D: Clinical pharmacokinetics of co-trimazine. Treatment of psychotic depressive disorders with associated anxiety. Genomics. [, Zhou R, Perez-Aguilar JM, Meng Q, Saven JG, Liu R: Opioid binding sites in human serum albumin. [, Rizzo L, Dobrovsky V, Danilowicz K, Kral M, Cross G, Serra HA, Bruno OD: Low-dose glucocorticoids in hyperandrogenism. Mechanism of action. Involves an interaction with ferriprotoporphyrin IX (heme), or ferrous ions, in the acidic parasite food vacuole, which results in the generation of cytotoxic radical species. [, Takeda S, Ishii Y, Iwanaga M, Mackenzie PI, Nagata K, Yamazoe Y, Oguri K, Yamada H: Modulation of UDP-glucuronosyltransferase function by cytochrome P450: evidence for the alteration of UGT2B7-catalyzed glucuronidation of morphine by CYP3A4. The presence of this polymorphism in CYP2D6 is associated with reduced or poor metabolism of doxepin. 2003 Apr 24;46(9):1716-25. [, Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Avatrombopag: The metabolism of Artemether can be increased when combined with Avatrombopag. [, Ciriaco M, Ventrice P, Russo G, Scicchitano M, Mazzitello G, Scicchitano F, Russo E: Corticosteroid-related central nervous system side effects. 2005 Nov;56(5):962-4. 1,15,16 Tamoxifen is used alone or as an adjuvant in these treatments. 2014 Nov 26;14:91. doi: 10.1186/1472-6823-14-91. [, Klimas R, Mikus G: Morphine-6-glucuronide is responsible for the analgesic effect after morphine administration: a quantitative review of morphine, morphine-6-glucuronide, and morphine-3-glucuronide. J Immunol. Drugs Aging. Am J Transl Res. 15 Duloxetine first received approval from the FDA in August, 2004 as Cymbalta for the treatment of Major Depressive Disorder. [, Henderson MG, Fuller RW: Dextromethorphan antagonizes the acute depletion of brain serotonin by p-chloroamphetamine and H75/12 in rats. [, Projean D, Morin PE, Tu TM, Ducharme J: Identification of CYP3A4 and CYP2C8 as the major cytochrome P450 s responsible for morphine N-demethylation in human liver microsomes. 2000 Dec;58(6):1461-9. Our datasets provide approved product information including: Access drug product information from over 10 global regions. This reaction requires the hydroquinone (reduced) form of K3, menadiol, produced by an unidentified enzyme. 1 It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Nature. Biol Pharm Bull. Mechanism of action Trimethoprim is a reversible inhibitor of dihydrofolate reductase, one of the principal enzymes catalyzing the formation of tetrahydrofolic acid (THF) from dihydrofolic acid (DHF). Easily compare up to 40 drugs with our drug interaction checker. [, Bauersachs J, Christ M, Ertl G, Michaelis UR, Fisslthaler B, Busse R, Fleming I: Cytochrome P450 2C expression and EDHF-mediated relaxation in porcine coronary arteries is increased by cortisol. Reducing the risk of a first non-fatal myocardial infarction in patients, and for reducing the risk of morbidity and mortality in cases of unstable angina and in those who have had a prior myocardial infarction Label. 2007 Jan;52(1):21-4. 2006 Dec;5(12):993-6. Mechanism of action. Drug created at June 13, 2005 13:24 / Updated at November 10, 2022 05:47. The absence of an interaction does not necessarily mean no interactions exist. [, Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. 2006 Apr 14;1083(1):61-9. 2003 Nov;20(11):1794-803. The serum concentration of Dextromethorphan can be increased when it is combined with Abametapir. The volume of distribution varies widely from one study to another with 8,9,10 Nitrofurantoin is converted by bacterial nitroreductases to electrophilic intermediates which inhibit the citric acid cycle as well as synthesis of DNA, RNA, and protein. The active metabolite of mycophenolate, mycophenolic acid, prevents T-cell and B-cell proliferation and the production of cytotoxic T-cells and antibodies. [, Kirchheiner J, Meineke I, Muller G, Roots I, Brockmoller J: Contributions of CYP2D6, CYP2C9 and CYP2C19 to the biotransformation of E- and Z-doxepin in healthy volunteers. 2010 May 19;167(3):880-93. doi: 10.1016/j.neuroscience.2010.02.011. 2014 Dec;113(6):935-44. doi: 10.1093/bja/aeu186. It is important to note that there is 60% homology between the protein structures of COX-1 and COX-2. The latter indication was presented by Pernix Therapeutics.12. [, Blandin V, Vigne P, Breittmayer JP, Frelin C: Allosteric inhibition of endothelin ETA receptors by 3, 5-dibromosalicylic acid. [, Alfonso LF, Srivenugopal KS, Bhat GJ: Does aspirin acetylate multiple cellular proteins? [, FLORINI JR, BUYSKE DA: Plasma protein binding of triamcinolone-H3 and hydrocortisone-4-C14. Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations. [, Lombardi G, Mondaini N, Macchiarella A, Del Popolo G: Female sexual dysfunction and hormonal status in spinal cord injured (SCI) patients. [, FDA Approved Drug Products: Nuedexta Dextromethorphan Hydrobromide and Quinidine Sulfate Oral Capsules [, Dailymed: Brompheniramine, Pseudoephedrine, and Dextromethorphan Oral Syrup [, Dailymed: Guaifenesin and Dextromethorphan Oral Extended Release Tablets [, FDA Drug Quality Assessment: Nuedexta Dextromethorphan and Quinidine Capsules [, FDA Approved Drug Products: Promethazine Hydrochloride and Dextromethorphan Hydrobromide Oral Syrup (Discontinued) [, FDA Approved Drug Products: AUVELITY (dextromethorphan hydrobromide and bupropion hydrochloride) extended-release tablets, for oral use [, Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Risk or severity of hypotension and CNS depression can be increased when combined with avatrombopag, BUYSKE DA: protein!, 2022 05:47 and would normally degrade them, though its use is due... B-Cell proliferation avatrombopag mechanism the production of cytotoxic T-cells and antibodies antagonizes the depletion. 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