A series of Humira biosimilars are poised to hit the U.S. market in 2023. All Rights Reserved. Sign up for a free 7-day trial here. As a result, about 900 million shots could still be sold. The list of pharmaceutical products detailed above reflects the golden age of the blockbuster; the industry is no longer able to deliver products that hold this level of commercial potential to the market with nearly as much regularity. Lipitor still . Generating more than $59 billion in cumulative revenue in 2021, the vaccine added $36.8 billion to Pfizers bottom line in 2021. Disclosure: The author has a position in AbbVie. In hematological oncology, weve established a leading position with Imbruvica and Venclexta, which are both expected to remain important revenue contributors through the decade.. Current consensus forecasts indicate that sales of the anti-TNF product will peak at around $11.2 billion in 2016, before a steady decline driven in part by loss of market share to oral alternatives, such as Pfizers Xeljanz. Get in touch with us now. , increased manufacturing efforts, and global distribution. Closer analysis of cumulative sales across the five biggest selling products on a peak annual sales basis provides for some interesting trends. Heart drug Lipitor is the biggest-selling drug of all time. 1. Currently, there has been a significant growth of spending on novel medicines, which is reflected in the list of best-selling drugs. BRAFTOVI capsules (encorafenib) BUMETANIDE (bumetanide) BUPIVACAINE (bupivacaine hydrochloride) BUPRENORPHINE HYDROCHLORIDE (buprenorphine hydrochloride) BUSULFAN (busulfan) BUTORPHANOL TARTRATE (butorphanol tartrate) CADUET (amlodipine besylate/atorvastatin calcium) CALAN (verapamil hydrochloride) CALCIUM CHLORIDE (calcium chloride) CAMPTOSAR (2). The data forecasts the top 10 best-selling drugs in 2025 by annual revenue. plaque psoriasis, rheumatoid arthritis, psoriatic arthritis, juvenile idiopathic arthritis and ankylosing spondylitis. Prevenar13 from Pfizer takes spot number 12, and it is a pneumococcal vaccine that reached $5,850,000,000. Lipitor still generated $1.76 billion in sales for Pfizer in 2016, pushing its lifetime sales to $148.7 billion! It is indicated for inflammatory diseases. Whether peak annual Humira sales will ever reach the Lipitor benchmark is open to conjecture. The blockbuster drug, which is used to lower cholesterol levels, was first introduced to the. The COVID-19 pandemic helped stoke demand for apixaban given evidence that blood thinners could help reduce the death risk from patients with severe infections who are at risk for strokes and heart attacks. In addition, the company hopes that sales of the Gardasil vaccine for recombinant human papillomavirus can offset waning Keytruda sales in coming years. This drug outsells all other drugs, and . This is driven by a number of factors the later launch of certain brands, for example but also illustrates the robustness of leading biologic franchises that do not face direct substitutable generic competition. COVID vaccines are complex biologic products, and their manufacturing requires specialized experience, expertise, and equipment. | Pfizer's cholesterol fighter Lipitor is the biggest-selling drug of all time, at least for now. By 2015, if all Pfizer's marketing and distribution plans fall into place, the company should have a $3 billion blockbuster drug on its hands, bolstering its sales and bottom line at a time when . A closer look at the 5 top best-selling pharmaceuticals in 2021 1. last summerPfizer is demanding ransom for vaccine contracts. Since then, Abbott and eventually its spin-off AbbVie have hiked the drugs price more than two dozen price times. Keep the Republic: William Federer and Dr. Duke Pesta Speak Truth, Keep The Republic: Top-Down Govt and 2000 Mules, KTR: Supreme Court, CRT, COVID and Leslie Manookian on Lawsuits for, Keep the Republic: Live Report From the Peoples Convoy, Updates from, Exclusive: Unvaccinated at SRNS Considered Insider Threat by DOE. https://www.europeanpharmaceuticalreview.com/article/102539/top-10-drugs-by-annual-revenue-in-2025/, 4. It reached $4,996,000,000 in sales. I bet he does. Cells Dont Lie: Cancer is on the Rise Due To mRNA ICAN: CDCs V-Safe App Omitted Adverse Events of Special Interest. The company has sought to offset the impact of Humira biosimilar competition outside of the U.S. in recent years through price increases. Nicknamed "turbostatin," Lipitor became the top-selling statin barely three years after it was launched. Click here to check it out. In 2021, governments and healthcare systems spent US$36.9 billion on Pfizer's COVID-19 vaccine Comirnaty (tozinameran), making it the best-selling drug of the year and catapulting Pfizer to the . Humira (adalimumab). The Pharmaceutical Industry in Figures. The average price hike was 6.3%, and one in four price hikes exceeded the most recently available inflation rate for the 12-month period ending in November 2021. Pfizer's patent on the best-selling cholesterol-lowering drug of all-time, Lipitor, expired on Wednesday, opening the market for generic competitors for America's most popular medication. Reiterating and expanding on its statement from December, Pfizer explained: High- and middle-income countries pay more than low-income countries, but at a value that is significantly discounted from our normal benchmarks, during the pandemic. While many would argue the group would fare better by shifting its attention to alternative treatments (like Ivermectin), Tim Bierley, a pharma campaigner at the group, highlighted what UncoverDCreported last summerPfizer is demanding ransom for vaccine contracts. various cancers caused by human papillomavirus, HR-positive and HER2-negative breast cancer, plaque psoriasis, psoriatic arthritis, ankylosing spondylitis, relapsing or primary progressive multiple sclerosis. Research from GlobalData, as seen in the European Pharmaceutical Review, suggests that in four years, the top-selling drugs in the world will be Keytruda (cancer), Eliquis (anticoagulant). Interestingly, among the best-selling drugs, there is Revlimid that has an uncertain mechanism of action but that produces effective results, showing the importance of novel drugs and also the continued development of the pharmaceutical market. Not a Premium Member of GuruFocus? Pfizer Inc.'s (NYSE:PFE) Covid-19 vaccine is poised to knock AbbVie Inc.'s (NYSE:ABBV) Humira off the top perch and become the best-selling medication in pharmaceutical industry history.. 1. Reiterating and expanding on its statement from December, Pfizer explained: High- and middle-income countries pay more than low-income countries, but at a value that is significantly discounted from our normal benchmarks, during the pandemic. Revenue of $14.6 billion bested the Zacks estimate by more than $1 billion. For instance, Keytruda is employed for a course of treatment of about 2 years, although it can cause an autoimmune response. Spot number 20 is occupied by Xtandi that was produced by Astellas Pharma and Pfizer and is used for prostate cancer with a total annual sales number of $4,390,000,000. IQVIA believes that by the end of the year, 40% of the world's population will be in countries that have achieved herd mentality, and by the end of 2022, 70% of the world's population will be vaccinated. Opinions expressed by Forbes Contributors are their own. Pfizer is also betting on the future potential of mRNA-based vaccines. In the U.S., fourth-quarter sales increased 22% versus prior year, driven primarily by total prescription growth of 13%, Bristol Myers Squibb Chief Financial Officer David Elkins said on the companys 2021 Q4 earnings call. (Look out for more insights from our annual Pharma 50 report.). (2), Number 17 has Enbrel from Amgen for psoriasis, rheumatoid arthritis, and psoriatic arthritis, juvenile idiopathic arthritis, and ankylosing spondylitis. When Sony released the PlayStation in the . On a mission to break the monopoly of pricing power of drug corporations, P4AD recently released a report titled A New Year Brings The Same Old Bad Behavior By Big Pharma. Elaborating on Pfizers jab windfall, the report notes: Due to sales of its COVID-19 vaccine, which is set to be the best-selling drug of all time, Pfizer shattered profit records in 2021. Still, Pfizer wasnt alone in raising prices. Of the other products it is the small molecule, primary care drugs Plavix and Seretide that have accumulated the highest revenues over the past 11 years, at $73 billion and $62 billion, respectively. With the experience in clinical medicine, biotechnology, health industry and other fields, he is responsible for the research and development of plant medicine, functional food and health products. Warning! PUBLISHED: April 24, 2022 at 3:29 p.m. | UPDATED: April 24, 2022 at 3:29 p.m. Demand for COVID pills is set to make Pfizer Inc.'s Paxlovid among the fastest-selling treatments of all time,. Lifetime sales: $47.9 billion Patent protection? (2021). In 2021, Pfizer's top product was COVID-19 vaccine Comirnaty, generating 36.8 billion U.S. dollars in alliance revenues and direct sales. Modernas Spikevax COVID-19 vaccine generated $17.7 billion in revenue in 2021, making the drug the third-best-selling product of the year. Not a Premium Member of GuruFocus? Bristol-Myers also manufactures the drug, yet even with this competition Pfizer clearly has found a winner with this drug. Former head of Pfizer R&D John LaMattina has described its sales performance as an "aberration" that will not be repeated (the ramp in sales between 1997 and 2000 when revenues reached $5 billion is best described as staggering). The company seeks to reduce its reliance on Humira, which accounted for 36.8% of its revenue in 2021. To reduce risk, Merck has ramped up investment in its oncology pipeline. The two companies have thus dipped in the rankings in 2021 compared with last year. Rees, V. (2019). Humira now costs $2,984 per syringe, according to an investigation by the U.S. House of Representatives. Ocrevus is used for relapsing or primary progressive multiple sclerosis and Rituxan, from Roche and Pharmstandard, is used for autoimmune diseases, cancers, and certain types of vasculitis. Specifically, there is a significant emergence of countries like China, Brazil, and India that are becoming bigger players in this field and presenting a higher growth than the European and the American pharmaceutical markets. (2), At number 11, there is Xarelto from Janssen, reaching $6,498,020,000, which helps reduce the risk of stroke in atrial fibrillation and is used for deep vein thrombosis (DVT), pulmonary embolism, and DVT prophylaxis after surgery, specifically, knee or hip replacement. Lipitor. Projected sales for 2022 are $54.5 billion more than double the previous record for one-year sales for a prescription drug. rheumatoid arthritis, juvenile idiopathic arthritis, Rheumatoid arthritis, forms of juvenile idiopathic arthritis and giant cell arteritis as well as CAR T cell-induced severe or life-threatening cytokine release syndrome, Crohns disease, ulcerative colitis, rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, plaque psoriasis, urothelial carcinoma, non-small cell lung cancer and triple-negative breast cancer, colorectal, lung, glioblastoma, kidney, cervical and ovarian cancer, chronic heart failure and reduced ejection fraction, asthma, airflow obstruction in patients with COPD, A closer look at the 5 top best-selling pharmaceuticals in 2021, The company has sought to offset the impact of Humira biosimilar competition outside of the U.S. in recent years through price increases. In a way, it reflects on the stability and importance of the pharmaceutical market to address the biggest health threats and also to provide medication that attacks chronic conditions and high-risk conditions like cancer. Hugh Pickens writes "The U.S. patent has just expired on Lipitor, the best-selling drug of all time, as the first generic versions go on sale, marking the end of a brand that has dominated the drug industry, lowered the cholesterol of tens of millions of patients, and generated $10.7 billion last year in annual sales.But drug manufacturer Pfizer, dependent on Lipitor for almost one-fifth of . Pfizer Inc.'s (NYSE:PFE) Covid-19 vaccine is poised to knock AbbVie Inc.'s (NYSE:ABBV) Humira off the top perch and become the best-selling medication in pharmaceutical industry history. In the past year, Pfizer shares have gained 13% to near $40. This article first appeared on GuruFocus. It reached $19,832,000,000 in sales worldwide. Pfizer has only one brand in the Top 10 list - Eliquis. Pfizer and BioNTech split vaccine sales after deducting the cost of the products, although Pfizer records the "vast majority" of global revenue. AbbVide and Janssen sold Imbruvica (No.6) or ibrutinib for $9,442,000,000. Pfizer expects to earn about $36 billion in revenue this year from the COVID vaccine developed with BioNTech, the company announced Tuesday an increase from the previous estimate of $33.5 billion. but that Lipitor is in danger of being overthrown as the most commercially successful drug of all time. Translations in context of "all-time top-selling drugs" in English-Spanish from Reverso Context: Since then, statin drugs like Lipitor became one of the all-time top-selling drugs in history (Angell, 2005). Lipitor By a wide margin, Pfizer's Lipitor qualifies as the best-selling drug of all time. Tellingly, each of the products in the list abovebest positioned to record an increase in peak annual sales over the next five years is a biologic; Humira, Enbrel, Rituxan, Herceptin and Lantus being the chief candidates. The 15 All-Time Best-Selling Prescription Drugs. Lipitor, which was introduced by Pfizer back in 1997, is expected to be the drug with the third highest lifetime sales as of 2026. Protecting itself further, Pfizer responded the Global Justice Nows claims earlier this week, insisting it was firmly committed to equitable and affordable access to its COVID-19 gene-therapyjabs. However, the susceptibility of this product type to generic erosion is illustrated by forecast cumulative revenues for Plavix over the next five years, at $16.1 billion.
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